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ID: 124813.0, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Concentration dependence of lumped mass transfer coefficients : linear vs. nonlinear chromatography and isocratic vs. gradient operation
Authors:Antos, D.; Kaczmarski, K.; Piatkowski, W.; Seidel-Morgenstern, A.
Date of Publication (YYYY-MM-DD):2003
Title of Journal:Journal of Chromatography A
Start Page:61
End Page:76
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The general rate model provides a reliable platform to predict elution bands in both linear and non-linear chromatography provided the required equilibrium functions and the coefficients quantifying the mass transfer in and around the particles are available. If further the variation of the equilibrium functions with changes in the mobile phase composition is known, this model is also able to predict gradient elution chromatography. Significant disadvantages of the model are the need to specify three kinetic coefficients and the amount of computing time required for the numerical solution of the underlying equations. Thus, several simplified models have been suggested lumping mass transfer resistances together. In this work the accuracy of predicting chromatographic bands based on the numerical solution of two lumped models has been analyzed. Elution profiles calculated by (a) the transport-dispersive and (b) the equilibrium-dispersive models were compared between each other and with the solution of the more detailed general rate model. In the analysis performed both linear and non-linear chromatography was considered under isocratic and gradient conditions.
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
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