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ID: 13147.0, MPI für neurologische Forschung / Emeritus-Collection Prof. Heiss
The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state
Authors:Rudolf, Jobst; Sobesky, Jan; Ghaemi, Mehran; Heiss, Wolf-Dieter
Date of Publication (YYYY-MM-DD):2002-11
Title of Journal:European Journal of Neurology
Journal Abbrev.:Eur. J. Neurol.
Issue / Number:6
Start Page:671
End Page:677
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:This paper compares the results of parallel positron emission tomography ( PET) studies of regional cerebral glucose metabolism with the radiotracer F-18-fluorodeoxyglucose (FDG) and benzodiazepine receptor (BZR) density by PET using the BZR ligand C-11-flumazenil (FMZ), a tracer of neuronal integrity, in nine patients with acute vegetative state (AVS, duration <1 month). Overall glucose utilization was significantly reduced in AVS in comparison with age-matched controls (global metabolic rate for glucose 26 μmol/100 g/min in AVS vs. 31 μmol/100g/min in controls). FMZ-PET demonstrated a considerable reduction of BZR binding sites in all cortical regions that grossly corresponded to the extent of reduction of cerebral glucose metabolism assessed with FDG-PET, whilst the cerebellum was spared from neuronal loss. In controls, cortical relative flumazenil binding was not lower than five times the average white matter activity, whilst in AVS, nearly all values were below this threshold. There was no relevant overlap of the data of relative umazenil binding between both groups. The comparison of FDG- and FMZ-PET findings in AVS demonstrates that alterations of cerebral glucose consumption do not represent mere functional inactivation, but irreversible structural brain damage.
Free Keywords:acute vegetative state; C-11-flumazenil; positron emission tomography; post-anoxic syndromes; prognosis
Comment of the Author/Creator:Date: 2002, NOV
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für neurologische Forschung/Allgemeine Neurologie (PET) - Abt. Prof. Heiss
External Affiliations:Univ Cologne, Neurol Klin, Joseph Stelzmann Str 9, D-50924; Cologne, Germany; Univ Cologne, Neurol Klin, D-50924 Cologne, Germany; Max Planck Inst Neurol Res, D-50931 Cologne, Germany
Identifiers:ISI:000179547400017 [ID No:1]
ISSN:1351-5101 [ID No:2]
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