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ID: 13766.0, MPI für Dynamik komplexer technischer Systeme / Systems Biology
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
Authors:Schöberl, B.; Eichler-Jonsson, C.; Gilles, E. D.; Müller, G.
Language:English
Date of Publication (YYYY-MM-DD):2002-04
Title of Journal:Nature Biotechnology
Journal Abbrev.:Nat. Biotechnol.
Volume:20
Issue / Number:4
Start Page:370
End Page:375
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:We present a computational model that offers an integrated quantitative, dynamic, and topological representation of intracellular signal networks, based on known components of epidermal growth factor (EGF) receptor signal pathways. The model provides insight into signal-response relationships between the binding of EGF to its receptor at the cell surface and the activation of downstream proteins in the signaling cascade. It shows that EGF-induced responses are remarkably stable over a 100-fold range of ligand concentration and that the critical parameter in determining signal efficacy is the initial velocity of receptor activation. The predictions of the model agree well with experimental analysis of the effect of EGF on two downstream responses, phosphorylation of ERK-1/2 and expression of the target gene, c-fos.
External Publication Status:published
Document Type:Article
Communicated by:Ernst-Dieter Gilles
Affiliations:MPI für Dynamik komplexer technischer Systeme/Systems Biology
External Affiliations:Univ Stuttgart, Inst Cell Biol & Immunol, Allmandring 31, D-70569 Stuttgart, Germany; Univ Stuttgart, Inst Syst Dynam & Control, D-70569 Stuttgart, Germany
Identifiers:ISI:000174681900024
ISSN:1087-0156
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