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ID: 16706.0, MPI für biophysikalische Chemie / Abteilungsunabhängige Arbeitsgruppen
Guidance of primordial germ cell migration by the chemokine SDF-1
Authors:Doitsidou, M.; Reichman-Fried, M.; Stebler, J.; Koeprunner, M.; Doerries, J.; Meyer, D.; Esguerra, C. V.; Leung, T.; Raz, E.
Language:English
Date of Publication (YYYY-MM-DD):2002-11-27
Title of Journal:Cell
Volume:111
Issue / Number:5
Start Page:647
End Page:659
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The signals directing primordial germ cell (PGC) migration in vertebrates are largely unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are found and toward which they migrate in wild-type as well as in mutant embryos in which PGC migration is abnormal. Knocking down SDF-1 or its receptor CXCR4 results in severe defects in PGC migration. Specifically, PGCs that do not receive the SDF-1 signal exhibit lack of directional movement toward their target and arrive at ectopic positions within the embryo. Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs.
Comment of the Author/Creator:Date: 2002, NOV 27
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/AG Erez Raz
External Affiliations:Univ Freiburg, Inst Biol 1, Dept Dev Biol, D-79104 Freiburg, Germany; Mermaid Pharmaceut GmbH, D-20251 Hamburg, Germany
Identifiers:URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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