Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Display Documents



  history
ID: 16927.0, MPI für biophysikalische Chemie / Molekulare Zellbiologie (Prof. Peter Gruss)
Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TR alpha gene
Authors:Flamant, F.; Poguet, A. L.; Plateroti, M.; Chassande, O.; Gauthier, K.; Streichenberger, N.; Mansouri, A.; Samarut, J.
Language:English
Date of Publication (YYYY-MM-DD):2002-01
Title of Journal:Molecular Endocrinology
Volume:16
Issue / Number:1
Start Page:24
End Page:32
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Mice devoid of all TRs are viable, whereas Pax8(-/-)mice, which lack the follicular cells producing T-4 and T-3 in the thyroid gland, die during the first weeks of postnatal life. A precise comparison between the two types of mutants reveals that their phenotypes are similar, but the defects in spleen, bone, and small intestine are more pronounced in Pax(-/-) mice. This is interpreted as the result of a negative effect of the unliganded TR on thyroid hormone target genes expression in the Pax(-/-)mutants. Pax8(-/-) compound mutants can survive to adulthood, and the expression of target genes is partially restored. This demonstrates the importance of TR alpha aporeceptor activity in several aspects of postnatal development.
Comment of the Author/Creator:Date: 2002, JAN
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/AG Ahmed Mansouri
External Affiliations:Ecole Normale Super Lyon, Biol Cellulaire & Mol Lab, CNRS, UMR; 5665,INRA LA 913, 46 Allee Italie, F-69364 Lyon 07, France; Ecole Normale Super Lyon, Biol Cellulaire & Mol Lab, CNRS, UMR 5665,INRA LA 913, F-69364 Lyon 07, France; Univ Lyon 1, Fac Med Laennec, Lab Histol & Embryol Mol, F-69372 Lyon, France
Identifiers:URL:http://mend.endojournals.org/cgi/reprint/16/1/24
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.