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ID: 16942.0, MPI für biophysikalische Chemie / Membranbiophysik (Prof. Erwin Neher)
Erucylphosphocholine-induced apoptosis in chemoresistant glioblastoma cell lines: Involvement of caspase activation and mitochondrial alterations
Authors:Jendrossek, V.; Kugler, W.; Erdlenbruch, B.; Eibl, H.; Lang, F.; Lakomek, M.
Language:English
Date of Publication (YYYY-MM-DD):2001-09
Title of Journal:Anticancer Research
Volume:21
Issue / Number:5
Start Page:3389
End Page:3396
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Intrinsic chemoresistance constitutes a major problem in the therapy of malignant gliomas. In vitro experiments with four astrocytoma/glioblastoma (AC/GBM) cell lines revealed that the chemoresistance of two cell lines, A 172 and T98G, to cisplatin and etoposide was due to resistance to drug-induced apoptosis. In contrast, all the AC/GBM cell lines tested were sensitive to treatment with the lipophilic ether lipid erucylphosphocholine, ErPC. ErPC-induced apoptosis was independent of wild-type p53- signaling and triggering of the CD95/CD95 ligand (CD95L) system. Inhibition of protein and RNA synthesis by cycloheximide and actinomycin D did not abrogate ErPC-induced apoptosis. However, expression of members of the bcl-2 protein family was modulated during ErPC treatment. Activation of caspase 3 and mitochondrial alterations were central to ErPC- induced apoptosis. We conclude that ErPC-induced activation of the mitochondrial pathway enables cell death in the chemoresistant AC/GBM cells.
Free Keywords:chemoresistance; glioblastoma cell lines; apoptosis; mitochondria; caspases; bcl-xL; erucylphosphocholine
Comment of the Author/Creator:Date: 2001, SEP-OCT
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/AG Hans-Jörg Eibl
External Affiliations:Univ Tubingen, Dept Physiol, Sch Med, Gmelinstr 5, D-72076; Tubingen, Germany; Univ Tubingen, Dept Physiol, Sch Med, D-72076 Tubingen, Germany; Univ Gottingen, Dept Pediat, Sch Med, D-37075 Gottingen, Germany
Identifiers:URL:http://www.scopus.com/record/display.url?eid=2-s2....
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