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ID: 17037.0, MPI für biophysikalische Chemie / Molekulare Zellbiologie (Prof. Peter Gruss)
Rotatin is a novel gene required for axial rotation and left- right specification in mouse embryos
Authors:Faisst, A. M.; Alvarez-Bolado, G.; Treichel, D.; Gruss, P.
Language:English
Date of Publication (YYYY-MM-DD):2002-04
Title of Journal:Mechanisms of Development
Volume:113
Issue / Number:1
Start Page:15
End Page:28
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The genetic cascade that governs left-right (L-R) specification is starting to be elucidated. In the mouse, the lateral asymmetry of the body axis is revealed first by the asymmetric expression of nodal, lefry2 and pitx2 in the left lateral plate mesoderm of the neurulating embryo. Here we describe a novel gene, rotatin, essential for the correct expression of the key L-R specification genes nodal, lefty and Pitx2. Embryos deficient in rotatin show also randomized heart looping and delayed neural tube closure, and fail to undergo the critical morphogenetic step of axial rotation. The amino acid sequence deduced from the cDNA is predicted to contain at least three transmembrane domains. Our results show a novel key player in the genetic cascade that determines L-R specification, and suggest a causal link between this process and axial rotation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Free Keywords:axial rotation; mouse; gene trap; beta-galactosidase reporter; left-right development; nodal; lefty-2; Pitx2
Comment of the Author/Creator:Date: 2002, APR
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Peter Gruss / 160
MPI für biophysikalische Chemie/Abt. Gregor Eichele
MPI für biophysikalische Chemie/AG Alvarez-Bolado
Identifiers:URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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