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ID: 17138.0, MPI für biophysikalische Chemie / Theoretische und computergestützte Biophysik (Dr. Helmut Grubmüller)
Force spectroscopy of single biomolecules
Authors:Rief, M.; Grubmueller, H.
Language:English
Date of Publication (YYYY-MM-DD):2002-03-12
Title of Journal:ChemPhysChem
Volume:3
Issue / Number:3
Start Page:255
End Page:261
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Many processes in the body are effected and regulated by highly, specialized protein molecules: These molecules certainly deserve name "biochemical nonomachines". Recent progress in single-molecule experiments and corresponding simulations with super,computers enable us to watch these "nanomachines" at work, revealing a host of astounding mechanisms. Examples are the fine-tuned movements of the binding pocket of a receptor protein,locking into its ligand molecule and the forced unfolding of titin, which acts as a molecular shock absorber to protect muscle cells. At present, we are not capable of designing such high precision machines, but we are beginning to understand their working principles and to simulate and predict their function.
Free Keywords:atomic force microscopy; molecular dynamics simulations; molecular recognition; protein folding; single molecules
Comment of the Author/Creator:Date: 2002, MAR 12
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Helmut Grubmüller / 070
External Affiliations:Univ Munich, Lehrstuhl Angew Phys Biophys & Neue mat,; Amalienstr 54, D-80799 Munich, Germany
Identifiers:URL:http://onlinelibrary.wiley.com/doi/10.1002/1439-76...
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