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ID: 17152.0, MPI für biophysikalische Chemie / Spektroskopie und photochemische Kinetik (Prof. Jürgen Troe)
Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins: perspectives from protein- lipid interactions (Review)
Authors:Marsh, D.; Horvath, L. I.; Swamy, M. J.; Mantripragada, S.; Kleinschmidt, J. H.
Date of Publication (YYYY-MM-DD):2002-10
Title of Journal:Molecular Membrane Biology
Issue / Number:4
Start Page:247
End Page:255
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Studies of lipid-protein interactions in double-reconstituted systems involving both integral and peripheral or lipid- anchored proteins are reviewed. Membranes of climyristoyl phosphatidylglycerol containing either myelin proteolipid protein or cytochrome c oxidase were studied. The partner peripheral proteins bound to these membranes were myelin basic protein or cytochrome c, respectively. In addition, the interactions between the myelin proteolipid protein and avidin that was membrane-anchored by binding to N-biotinyl phosphatidylethanolamine were studied in dimyristoyl phosphatidylcholine membranes. Steric exclusion plays a significant role when sizes of the peripheral protein and transmembrane domain of the integral protein are comparable. Even so, the effects on avidin-linked lipids are different from those induced by myelin basic protein on freely diffusible lipids, both interacting with the myelin proteolipid protein. Both the former and the cytochrome c/cytochrome oxidase couple evidence a propagation of lipid perturbation out from the intramembrane protein interface that could be a basis for formation of microdomains.
Free Keywords:lipid-protein interactions; spin labels; electron spin resonance; myelin proteins; cytochrome oxidase; avidin-biotin
Comment of the Author/Creator:Date: 2002, OCT-DEC
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Jürgen Troe / 010
External Affiliations:Biol Res Ctr, Inst Biophys, H-6701 Szeged, Hungary; Univ Hyderabad, Sch Chem, Hyderabad 5000046, Andhra Pradesh, India; Skye Pharma, San Diego, CA 92121 USA; Univ Konstanz, Fachbereich Biol, D-7750 Constance, Germany
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