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ID: 173756.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Protein and antibody microarray technology
Authors:Glokler, Joern; Angenendt, Philipp
Language:English
Date of Publication (YYYY-MM-DD):2003-11-25
Title of Journal:Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Journal Abbrev.:J. Chromatogr. B
Volume:797
Issue / Number:1-2
Start Page:229
End Page:240
Title of Issue:Interactions in Biological Systems
Copyright:Copyright © 2003 Elsevier B.V. All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Following the age of genomics having sequenced the human genome, interest is shifted towards the function of genes. This new age of proteomics brings about a change of methods to study the properties of gene products on a large scale. Protein separation technologies are now applied to allow high-throughput purification and characterisation of proteins. Two-dimensional-gel electrophoresis (2DE) and mass spectrometry (MS) have become widely used tools in the field of proteomics. At the same time, protein and antibody microarrays have been developed as successor of DNA microarrays to soon allow the proteome-wide screening of protein function in parallel. This review is aimed to introduce this new technology and to highlight its current prospects and limitations.
Free Keywords:review, microarray technologies, proteomics, proteins, antibodies
Comment of the Author/Creator:Available online 20 October 2003.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Max Planck Institut fuer Moleculare Genetik, Ihnestrasse 73, 14195, Berlin, Germany
Identifiers:ISI:000186844600014 [ID No:1]
ISSN:1570-0232 [ID No:2]
DOI:10.1016/j.jchromb.2003.08.034 [ID No:3]
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