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ID: 173773.0, MPI für molekulare Genetik / Independent Junior Research Groups (Otto-Warburg-Laboratory)
SIR-dependent repression of non-telomeric genes in Saccharomyces cerevisiae?
Authors:Marchfelder, Uta; Rateitschak, Katja; Ehrenhofer-Murray, Ann E.
Language:English
Date of Publication (YYYY-MM-DD):2003-07-15
Title of Journal:Yeast
Journal Abbrev.:Yeast
Volume:20
Issue / Number:9
Start Page:797
End Page:801
Copyright:© 2003 John Wiley & Sons, Ltd
Review Status:not specified
Audience:Experts Only
Abstract / Description:The proteins Sir2, Sir3 and Sir4 repress transcription of the silent mating-type loci HML and HMR and of reporter genes inserted at telomeres. Previous microarray analyses suggested that additional non-telomeric genes exist which are repressed by the Sir proteins. In this study, we tested the expression of 12 such genes by Northern analysis and RT-PCR. However, we were unable to verify their SIR-dependent regulation, which suggests that SIR-mediated repression may be restricted to the known repressed regions.
Free Keywords:silencing; chromatin; heterochromatin; Saccharomyces cerevisiae
Comment of the Author/Creator:Date: 2003, Jul 15
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:OWL-Group
Affiliations:MPI für molekulare Genetik
External Affiliations:Max Planck Inst Mol Genet, Otto Warburg Labs, D-14195 Berlin, Germany.; Max Planck Inst Mol Genet, Dept Computat Mol Biol, D-14195 Berlin, Germany
Identifiers:ISI:000184124100004 [ID No:1]
ISSN:0749-503X [ID No:2]
DOI:10.1002/yea.1001 [ID No:3]
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