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ID: 176039.0, MPI für Evolutionsbiologie / Evolutionary ecology
Sequence analysis of the MHC class II DRB alleles in Alpine chamois (Rupicapra r. rupicapra)
Authors:Schaschl, Helmut; Goodman, Simon J.; Suchentrunk, Franz
Language:English
Date of Publication (YYYY-MM-DD):2004-03
Title of Journal:Developmental and Comparative Immunology
Volume:28
Issue / Number:3
Start Page:265
End Page:277
Review Status:not specified
Audience:Not Specified
Abstract / Description:This study characterises the expressed MHC class 11 DRB gene and its genetic variation in exon 2 among 59 Alpine chamois (Rupicapra r. rupicapra) from several locations in the Eastern Alps plus one population in the Western Alps. The expressed DRB gene contains all the expected characteristics including all of the conserved residues found in other mammalian species. The isolated expressed DRB gene from chamois can be considered orthologous to MHC class 11 DRB genes in other mammalian species. Cattle primers yielded exon 2 sequences of 284 bp length. Sequence analysis revealed 19 DRB exon 2 alleles among 59 chamois. Alleles exhibited a high degree of nucleotide and amino acid polymorphism, with most amino acid variations occurring at positions forming the peptide-binding sites. A significantly higher rate of non-synonymous (dN = 0.053 ± 0.0132) than synonymous (dS = 0.007 ± 0.003) substitutions indicated positive selection for diversity in the DRB locus.
Free Keywords:MHC; class II beta chain; allelic polymorphism; chamois; caprinae
External Publication Status:published
Document Type:Article
Affiliations:MPI für Limnologie/Abt. Evolutionsökologie
External Affiliations:Vet Med Univ Vienna, Res Inst Wildlife Ecol, Vienna, A-1160 Austria; Zool Soc London, Inst Zool, London, NW1 4RY England
Identifiers:ISSN:0145-305X [ID-No:1]
DOI:10.1016/j.dci.2003.08.003 [ID-No:2]
LOCALID:2300/S 38175 [Listen-Nummer/S-Nummer]
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