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ID: 199018.0, MPI für biophysikalische Chemie / Molekulare Biologie (Dr. Thomas M. Jovin)
Novel (bio)chemical and (photo)physical probes for imaging live cells
Authors:Jares-Erijman, E. A.; Spagnuolo, C.; Giordano, L.; Etchehon, M.; Kawior, J.; Manalich-Arana, M. V.; Bossi, M.; Lidke, D. S.; Post, J. N.; Vermeij, R. J.; Heintzmann, R.; Lidke, K. A.; Arndt-Jovin, D. J.; Jovin, T. M.
Language:English
Place of Publication:Amsterdam
Publisher:Kluwer
Date of Publication (YYYY-MM-DD):2004
Title of Book:Supramolecular structure and function 8. Proceedings of the 8. Int. Summer School on Biophysics: Supramolecular structure and function, Sept. 14 - 26, 2003, Rovinj, Croatia
Start Page:99
End Page:118
Full Name of Book-Editor(s):Pifat-Mrzljak, Greta
Review Status:not specified
Audience:Not Specified
Abstract / Description:Emerging technologies, utilizing a combination of chemistry, physics and molecular biology, are creating an increasing interest in smart materials serving as reporters and sensors in micro- and nano-systems. Such devices constitute unique tools for a plethora of biological applications and therapies, allowing in vivo and real time monitoring of biomolecular structure and function. Imaging live cells poses a number of problems, not the least of which is to minimize the perturbation of the physiological state and viability of the cells with the probes and "tools". One seeks to achieve single molecule sensitivity (when appropriate and desirable), monitor fast kinetic processes, and observe molecular interactions occurring on distance scales far beyond the optical resolution of light microscopes. In the remainder of this contribution we discuss a few methods that have already attained some of these goals and present some model systems that hold the promise for achieving others. (excerpt from Section 2, this article contains no abstract)
Last Change of the Resource (YYYY-MM-DD):2004-09-29
External Publication Status:published
Document Type:InBook
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Thomas Jovin / 060
External Affiliations:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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