Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Display Documents



  history
ID: 20754.0, MPI für biophysikalische Chemie / Ehemalige Abteilungen
The riddle of the Sec1/Munc-18 proteins - new twists added to their interactions with SNAREs
Authors:Gallwitz, D.; Jahn, R.
Language:English
Date of Publication (YYYY-MM-DD):2003-03
Title of Journal:Trends in Biochemical Sciences
Volume:28
Issue / Number:3
Start Page:113
End Page:116
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Sec1/Munc-18 (SM) proteins are essential for intracellular membrane fusion reactions. Most of them bind to membrane- associated soluble N-ethylmaleimide-sensitive fusion (NSF)- attachment protein receptors (SNAREs) of the syntaxin subfamily but it is unclear whether regulating syntaxins is their primary role. Recent studies now have shown that the mechanism of syntaxin binding is not conserved, even though the structures of both protein families are. Amazing as this might be for those considering the evolution of conserved folds, it leaves the question of how SM proteins operate in membrane fusion unanswered.
Comment of the Author/Creator:Date: 2003, MAR
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Dieter Gallwitz / 150
MPI für biophysikalische Chemie/Abt. Reinhard Jahn / 190
Identifiers:URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.