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ID: 20758.0, MPI für biophysikalische Chemie / Membranbiophysik (Prof. Erwin Neher)
Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation
Authors:Felmy, F.; Neher, E.; Schneggenburger, R.
Language:English
Date of Publication (YYYY-MM-DD):2003-03-06
Title of Journal:Neuron
Volume:37
Issue / Number:5
Start Page:801
End Page:811
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:In nerve terminals, residual Ca2+ remaining from previous activity can cause facilitation of transmitter release by a mechanism that is still under debate. Here we show that the intracellular Ca2+ sensitivity of transmitter release at the calyx of Held is largely unchanged during facilitation, which leaves an increased microdomain Ca2+ signal as a possible mechanism for facilitation. We measured the Ca2+ dependencies of facilitation, as well as of transmitter release, to estimate the required increment in microdomain Ca2+. These measurements show that linear summation of residual and microdomain Ca2+ accounts for only 30% of the observed facilitation. However, a small degree of supra-linearity in the summation of intracellular Ca2+ signals, which might be caused by saturation of cytosolic Ca2+ buffer(s), is sufficient to explain facilitation at this CNS synapse.
Comment of the Author/Creator:Date: 2003, MAR 6
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Erwin Neher / 140
Identifiers:URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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