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ID: 221111.0, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Experimental Study and Simplified Mathematical Description of Preferential Crystallization
Authors:Elsner, M. P.; Fernandez Menendez, D.; Alonso Muslera, E.; Seidel-Morgenstern, A.
Language:English
Date of Publication (YYYY-MM-DD):2005
Title of Journal:Chirality
Volume:17
Issue / Number:S1 - Proceedings from the Sixteenth International Symposium on Chirality (16 ISCD), New York, USA, 2004
Start Page:S183
End Page:S195
Review Status:not specified
Audience:Experts Only
Abstract / Description:The purpose of this paper is to investigate the concept of preferential crystallization, with a focus on aspects of quantification and application from an engineering point of view. The amino acid threonine was used as a model system in the experiments performed. Application of on-line polarimetry in combination with measurements of an on-line density meter proved the general applicability of this method in order to monitor directly the resolution progress, to recognize the region of safe resolution, and to gain information about the crystallization kinetics. For evaluation of the crystal growth kinetics of the desired enantiomers, the method of moments was applied to analyze isothermal single-step crystallization experiments. A population balance model is used in order to simulate the time changes of liquid-phase composition during the preferential crystallization process. Finally, preliminary experimental results regarding the cyclic operation mode are presented.

Copyright © 2005 Wiley-Liss, Inc., A Wiley Company [accessed February 8th 2013]
Free Keywords:enantioseparation; entrainment effect; conglomerates; threonine; method of moments; crystal growth; nucleation; population balance
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
External Affiliations:Institute of Process Engineering, Otto von Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany
Identifiers:URL:http://dx.doi.org/10.1002/chir.20135
LOCALID:19/05
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