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ID: 233597.0, MPI für Evolutionsbiologie / Evolutionary ecology
Parasites and individual major histocompatibility complex diversity—an optimal choice?
Authors:Wegner, K. Mathias; Kalbe, Martin; Schaschl, Helmut; Reusch, Thorsten B. H.
Language:English
Date of Publication (YYYY-MM-DD):2004-10
Title of Journal:Microbes and Infection
Volume:6
Issue / Number:12
Start Page:1110
End Page:1116
Review Status:not specified
Audience:Not Specified
Abstract / Description:Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges.
Free Keywords:major histocompatibility complex (MHC); parasites; host-parasite coevolution; balancing selection; heterozygote advantage; mate choice
External Publication Status:published
Document Type:Article
Affiliations:MPI für Limnologie/Abt. Evolutionsökologie
Identifiers:ISSN:1286-4579 [ID-No:1]
DOI:doi:10.1016/j.micinf.2004.05.025 [ID-No:2]
LOCALID:2365/S 38387 [Listen-Nummer/S-Nummer]
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