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ID: 24572.0, MPI für molekulare Genetik / Sequencing Group
Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region
Authors:Sudbrak, Ralf; Reinhardt, Richard; Hennig, Steffen; Günther, Eberhard; Walter, Lutz
Language:English
Date of Publication (YYYY-MM-DD):2002-12-10
Title of Journal:Immunogenetics
Volume:54
Issue / Number:10
Start Page:699
End Page:704
Review Status:not specified
Audience:Experts Only
Abstract / Description:The sequence-based map of a part of the rhesus macaque major histocompatibility complex (MHC) extended class II region is presented. The sequenced region encompasses 67,401 bp and contains the SACM2L, RING1, FABGL and KE4 genes, as well as the HTATSF1-like and ZNF-like pseudogenes. Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L-RING1 interval. The rhesus macaque extended MHC class II region shows a high degree of conservation of exonic as well as intronic and intergenic sequences compared with the respective human region. It is concluded that this particular genomic organization of the extended class II region--i.e., the absence of class I genes and the presence of the HTATSF1-like and ZNF-like pseudogenes--can be traced back to a common ancestor of humans and rhesus macaques about 23 million years ago.
Free Keywords:mhc, evolution, comparative sequence analysis, rhesus macaque
External Publication Status:published
Document Type:Article
Communicated by:Richard Reinhardt
Affiliations:MPI für molekulare Genetik
External Affiliations:Abteilung Immungenetik, Universität Göttingen, Heinrich-Düker-Weg 12, Göttingen
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