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ID: 273055.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Timing and mechanism of ancient vertebrate genome duplications – the adventure of a hypothesis
Authors:Panopoulou, Georgia; Poustka, Albert J.
Language:English
Date of Publication (YYYY-MM-DD):2005-08-15
Title of Journal:Trend in Genetics (Amsterdam)
Journal Abbrev.:Trends Genet
Volume:21
Start Page:559
End Page:567
Copyright:© 2005 Elsevier Ltd
Review Status:not specified
Audience:Experts Only
Abstract / Description:Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of vertebrates (known as the 2R hypothesis). However, there has been considerable debate as to whether these were two successive duplications, or whether a single duplication occurred, followed by large-scale segmental duplications. In this article, we review and compare the evidence for the 2R duplications from vertebrate genomes with similar data from other more recent polyploids.
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
Identifiers:ISSN:0168-9525
DOI:10.1016/j.tig.2005.08.004
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