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ID: 293565.0, MPI für Dynamik komplexer technischer Systeme / Bioprocess Engineering
Characterization and analytical issues on an influenza A virus production process
Authors:Genzel, Y.; Kalbfuss, B.; Ritter, J. B.; Schulze-Horsel, J.; Rapp, E.; Vester, D.; Reichl, U.
Language:English
Name of Conference/Meeting:Vaccines : Quality control, scale-up and manufacture
Place of Conference/Meeting:Hamburg, Germany
(Start) Date of Conference/Meeting
 (YYYY-MM-DD):
2006-12-05
End Date of Conference/Meeting 
 (YYYY-MM-DD):
2006-12-06
 Invitation status:invited
Audience:Experts Only
Abstract / Description:Different approaches for a mammalian cell culture based production process for influenza vaccines are currently in development. Each approach needs optimization based on analytical data collected from many small scale experiments. In the presentation results for different cultivation methods (rollerbottles, stirred tank or wave bioreactor microcarrier system) for a production process with adherent MDCK cells are discussed. Analytical data on cell numbers, metabolism, host cell protein level, cell cycle and virus titer are shown.
Document Type:Talk at Event
Communicated by:Udo Reichl
Affiliations:MPI für Dynamik komplexer technischer Systeme/Bioprocess Engineering
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