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ID: 307654.0, MPI für Evolutionsbiologie / Evolutionary ecology
Innate versus adaptive immunity in sticklebacks: evidence for trade-offs from a selection experiment
Authors:Wegner, K. Mathias; Kalbe, Martin; Reusch, Thorsten B. H.
Language:English
Date of Publication (YYYY-MM-DD):2007-07
Title of Journal:Evolutionary Ecology
Journal Abbrev.:Evol Ecol
Volume:21
Issue / Number:4
Start Page:473
End Page:483
Review Status:not specified
Audience:Not Specified
Abstract / Description:In vertebrates, the immune system consists of two arms of different characteristics: the innate and the acquired immune response. Parasites that are only shortly exposed to the immune system are most efficiently attacked by fast, constitutive innate immune mechanisms. Here, we experimentally selected within four fish families for high innate resistance versus susceptibility of three-spined sticklebacks (Gasterosteus aculeatus) against infection with the eye-fluke (Diplostomum pseudospathacaeum), a parasite whose metacercariae are protected from the immune system within the eye lens. We predicted that in families with high susceptibility, the adaptive immune system would be upregulated when challenged with infection. In accordance, we found that MHC class IIB expression is increased by
approximately 50% in those lines selected for higher parasite load (i.e. low innate response). This suggests extensive genetic correlations between innate and adaptive
immune system and/or crosstalk between both lines of defense. An efficient, specific innate immune response might reduce overall activation of the immune system and
potentially alleviate associated effects of immunopathology.
Free Keywords:Major histocompatibility complex (MHC); Ecological immunity;
Innate resistance; Adaptive immunity; Gene expression; Three-spined stickleback (Gasterosteus aculeatus); Parasites; Artificial selection
External Publication Status:published
Document Type:Article
Affiliations:MPI für Limnologie/Abt. Evolutionsökologie
External Affiliations:Institute of Integrative Biology, Experimental Ecology, ETH Zürich Universitätstrasse 16 CHN H72, 8092 Zürich, Switzerland; Institute for Evolution and Biodiversity, University of Münster, Hüfferstrasse 1, 48149 Münster,
Germany

123
Identifiers:ISSN:0269-7653 (Print) [ID-No:1]
ISSN:1573-8477 (Online) [ID-No:2]
DOI:10.1007/s10682-006-9129-5 [ID-No:3]
LOCALID:2562/S 38712 [Listen-Nummer/S-Nummer]
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