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ID: 336996.0, MPI für molekulare Genetik / Independent Junior Research Groups (Otto-Warburg-Laboratory)
Cellular signaling is potentially regulated by cell density in receptor trafficking networks
Authors:Zi, Zhike; Klipp, Edda
Language:English
Date of Publication (YYYY-MM-DD):2007-10-02
Title of Journal:FEBS Letters
Volume:581
Issue / Number:24
Start Page:4589
End Page:4595
Copyright:© 2008 Elsevier B.V.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Previous work has shown that receptor trafficking is a potential site for the control of signaling pathways. In most biological experiments, the ligand concentration and cell density vary within a wide range among different systems. However, there is less attention to systematically analyze how much cellular signal response is affected by cell densities. Here, we use a quantitative mathematical model to investigate signal responses in different receptor trafficking networks by simultaneous variations of ligand concentration and cell density. Computational analysis of the model revealed that receptor trafficking networks have potential sigmoid responses to ratio between ligand and surface receptor number per cell, which is a key factor to control the signaling responses in receptor trafficking networks. Furthermore, cell density also affects the robustness of dose–response curve upon the variation of binding affinity.
Free Keywords:Cell density; Receptor trafficking; Signal response; Systems biology
External Publication Status:published
Document Type:Article
Communicated by:OWL-Group
Affiliations:MPI für molekulare Genetik
External Affiliations:Theoretical Biophysics, Humboldt University Berlin, Institute for Biology. Invalidenstr. 42, 10115 Berlin, Germany
Identifiers:ISSN:0014-5793
DOI:10.1016/j.febslet.2007.08.047
URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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