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Home Search Quick Search Advanced Fulltext Browse Collections Persons My eDoc Session History Login Name: Password: Documentation Help Support Wiki Direct access to document ID:	Display Documents   history ID: 366470.1, Fritz-Haber-Institut / Inorganic Chemistry Cytotoxicity and Inflammatory Potential of Soot Particles of Low-Emission Diesel Engines Authors: Su, Dang Sheng; Serafino, Annalucia; Müller, Jens-Oliver; Jentoft, Rolf E.; Schlögl, Robert; Fiorito, Silvana Language: English Research Context: environmental carbon Date of Publication (YYYY-MM-DD): 2008-03-01 Title of Journal: Environmental Science and Technology Volume: 42 Issue / Number: 5 Start Page: 1761 End Page: 1765 Review Status: Peer-review Audience: Experts Only Abstract / Description: We evaluated, in vitro, the inflammatory and cytotoxic potential of soot particles from current low-emission (Euro IV) diesel engines toward human peripheral blood monocytederived macrophage cells. The result is surprising. At the same mass concentration, soot particles produced under lowemission conditions exhibit amuchhigher toxic and inflammatory potential than particles from an old diesel engine operating under black smoke conditions. This effect is assigned to the defective surface structure of Euro IV diesel soot, rendering it highly active. Our findings indicate that the reduction of soot emission in terms of mass does not automatically lead to a reduction of the toxic effects toward humans when the structure and functionality of the soot is changed, and thereby the biological accessibility and inflammatory potential of soot is increased. Free Keywords: soot particle, EURO IV diesel engine, in vitro, cytotoxic, human cells External Publication Status: published Document Type: Article Communicated by: Robert Schlögl Affiliations: Fritz-Haber-Institut/Inorganic Chemistry/Microstructure Fritz-Haber-Institut/Inorganic Chemistry/Inorganic Chemistry Fritz-Haber-Institut/Inorganic Chemistry/Preparation External Affiliations: Institute of Neurobiology and Molecular Medicine, National Research Council (CNR), Via Fosso del Cavaliere 100, 00133 Rome, Italy Identifiers: URL:http://pubs.acs.org/cgi-bin/abstract.cgi/esthag/20... [only subscribers] URL:http://dx.doi.org/10.1021/es0716554 Full Text: Sorry, no privileges The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.