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ID: 366470.1, Fritz-Haber-Institut / Inorganic Chemistry
Cytotoxicity and Inflammatory Potential of Soot Particles of
Low-Emission Diesel Engines
Authors:Su, Dang Sheng; Serafino, Annalucia; Müller, Jens-Oliver; Jentoft, Rolf E.; Schlögl, Robert; Fiorito, Silvana
Language:English
Research Context:environmental carbon
Date of Publication (YYYY-MM-DD):2008-03-01
Title of Journal:Environmental Science and Technology
Volume:42
Issue / Number:5
Start Page:1761
End Page:1765
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:We evaluated, in vitro, the inflammatory and cytotoxic potential of soot particles from current low-emission (Euro IV) diesel engines toward human peripheral blood monocytederived macrophage cells. The result is surprising. At the same mass concentration, soot particles produced under lowemission conditions exhibit amuchhigher toxic and inflammatory potential than particles from an old diesel engine operating under black smoke conditions. This effect is assigned to the defective surface structure of Euro IV diesel soot, rendering it highly active. Our findings indicate that the reduction of soot emission in terms of mass does not automatically lead to a reduction of the toxic effects toward humans when the structure and functionality of the soot is changed, and thereby the biological accessibility and inflammatory potential of soot is increased.
Free Keywords:soot particle, EURO IV diesel engine, in vitro, cytotoxic, human cells
External Publication Status:published
Document Type:Article
Communicated by:Robert Schlögl
Affiliations:Fritz-Haber-Institut/Inorganic Chemistry/Microstructure
Fritz-Haber-Institut/Inorganic Chemistry/Inorganic Chemistry
Fritz-Haber-Institut/Inorganic Chemistry/Preparation
External Affiliations:Institute of Neurobiology and Molecular Medicine, National Research Council (CNR), Via Fosso del Cavaliere 100, 00133 Rome, Italy
Identifiers:URL:http://pubs.acs.org/cgi-bin/abstract.cgi/esthag/20... [only subscribers]
URL:http://dx.doi.org/10.1021/es0716554
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