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ID: 404307.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis
Authors:Koestner, Ulrich; Shnitsar, Iryna; Linnemannstöns, Karen; Hufton, Andrew L.; Borchers, Annette
Language:English
Research Context:Funded by: Deutsche Forschungsgemeinschaft (DFG); Grant Number: BO1978/3-1; DFG Center for Molecular Physiology of the Brain (CMPB); Grant Number: B1-10; Christiane-Nüsslein-Volhard-Foundation.
Date of Publication (YYYY-MM-DD):2008-12-01
Title of Journal:Developmental Dynamics
Journal Abbrev.:Dev Dyn
Volume:237
Issue / Number:12
Start Page:3853
End Page:3863
Copyright:© 2008 John Wiley & Sons, Inc. All Rights Reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Semaphorins are major regulators of morphogenesis and are involved in a variety of processes ranging from the guidance of cell migration to the development of cancer. Since semaphorins were first characterized as repulsive neuronal guidance cues, their expression has been best documented in the nervous system. However, broader studies are lacking. Here, we describe the expression of 13 members of the semaphorin family and two neuropilin receptors during early Xenopus laevis development. No particular expression pattern defines any of the semaphorin classes, but many are dynamically expressed in distinct areas undergoing morphogenetic cell movements like the developing mesoderm and the migrating neural crest. Furthermore, the complementary expression patterns of Sema3A/Nrp1 and Sema3F/Nrp2 are maintained across hundreds of millions of years, possibly indicating a conserved role in the guidance of migrating neural crest cells.
Free Keywords:semaphorin • neuropilin • Xenopus • neural crest • convergent extension
Comment of the Author/Creator:email: Annette Borchers (annette.borchers@gmail.com)
Correspondence to Annette Borchers, Department of Developmental Biochemistry, GZMB, University of Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.
Ulrich Koestner and Iryna Shnitsar contributed equally to this work.
External Publication Status:published
Document Type:Article
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Department of Developmental Biochemistry, Center for Molecular Physiology of the Brain (CMPB), GZMB, University of Göttingen, Göttingen, Germany;
2.Department of Stem Cell Biology, GZMB, University of Göttingen, Göttingen, Germany.
Identifiers:URL:http://www3.interscience.wiley.com/cgi-bin/fulltex...
DOI:10.1002/dvdy.21785
ISSN:1058-8388
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