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ID: 411601.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Stemming cancer : functional genomics of cancer stem cells in solid tumors
Authors:Regenbrecht, Christian R. A.; Lehrach, Hans; Adjaye, James
Language:English
Date of Publication (YYYY-MM-DD):2008-11-09
Title of Journal:Stem Cell Reviews
Journal Abbrev.:Stem Cell Rev
Volume:4
Issue / Number:4
Start Page:319
End Page:328
Copyright:© Humana Press 2008
Review Status:not specified
Audience:Experts Only
Abstract / Description:Cancer stem cells (CSCs) were discovered about 15 years ago in hematopoietic cancers. Subsequently, cancer stem cells were discovered in various solid tumors. Based on parallels with normal stem cells, a developmental process of cancer stem cells follows paths of organized, hierarchical structure of cells with different degrees of maturity. While some investigators have reported particular markers as identification of cancer stem cells, these markers require further research. In this review, we focus on the functional genomics of cancer stem cells. Functional genomics provides useful information on the signaling pathways which are consecutively activated or inactivated amongst those cells. This information is of particular importance for cancer research and clinical treatment in many respects. (1) Understanding of self-renewal mechanisms crucial to tumor growth. (2) Allow the identification of new, more specific marker for CSCs, and (3) pathways that are suitable as future targets for anti-cancer drugs. This is of particular importance, because today’s chemotherapy targets the proliferating cancer cells sparing the relatively slow dividing cancer stem cells. The first step on this long road therefore is to analyze genome-wide expression-profiles within the same type of cancer and then between different types of cancer, encircling those target genes and pathways, which are specific to these cells.
Free Keywords:Cancer stem cell, Functional genomics, Genome-wide expression-profiling, Cell of origin, Tumor hierarchy, Self-renewal, Pathway-analysis
Comment of the Author/Creator:e-Mail: adjaye@molgen.mpg.de
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
Identifiers:ISSN:1550-8943
DOI:10.1007/s12015-008-9034-0
URL:http://springerlink.metapress.com/content/e633g17h...
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