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ID: 433492.0, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Theoretical study of preparative chromatography using closed-loop recycling with an initial gradient
Authors:Sreedhar, B.; Damtew, A.; Seidel-Morgenstern, A.
Date of Publication (YYYY-MM-DD):2009-06-19
Title of Journal:Journal of Chromatography A
Issue / Number:25
Start Page:4976
End Page:4988
Review Status:not specified
Audience:Experts Only
Abstract / Description:Complementing classical isocratic elution, several more sophisticated operating modes have been proposed and are applied in preparative chromatography in order to improve performance. One such approach is gradient elution, where the solvent strength is altered by varying the fraction of a modifier added to the mobile phase to enhance selectivity and to achieve faster elution. Another useful technique is closed-loop recycling, allowing better peak resolution and increased yields. This study focuses on a modified new scheme which incorporates the advantages of both gradient elution and closed-loop recycling for the separation of a ternary mixture where the intermediately eluting component is the target. A parametric study was carried out using typical adsorption isotherm parameters to elucidate the effects of varying loading factors and parameters specific to the two basic operational modes on production rates and yields. A comparison was also made between the proposed scheme and conventional techniques. It was found that the studied scheme could exploit increased column loadings and offers significantly higher production rates.
Copyright © 2009 Elsevier B.V. All rights reserved.
[accessed July 27, 2009]
Free Keywords:Preparative chromatography; Closed-loop recycling; Gradient elution; Closed-loop recycling with initial gradient; Parallel grid search; Optimization; Craig model
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
MPI für Dynamik komplexer technischer Systeme/International Max Planck Research School (IMPRS)
External Affiliations:Institut für Verfahrenstechnik, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany
URL:http://dx.doi.org/10.1016/j.chroma.2009.04.057 [Publisher's Homepage]
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