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ID: 570468.1, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Analysis and Comparison of Commonly Used Acidic Resolving Agents in Diastereomeric Salt Resolution – Examples for DL-Serine
Authors:Sistla, V. S.; von Langermann, J.; Lorenz, H.; Seidel-Morgenstern, A.
Language:English
Date of Publication (YYYY-MM-DD):2011
Title of Journal:Crystal Growth & Design
Volume:11
Issue / Number:9
Start Page:3761
End Page:3768
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Diastereomeric salt resolution is still the most relevant technique in chiral resolution processes, e.g. for pharmaceutical relevant substances. For this purpose the choice of a suitable corresponding resolving agent is very important in respect of optimal yield, chemical purity and diastereomeric excess. Thus the solid phase behavior of diastereomeric salts is a crucial parameter and should be investigated prior to any resolution experiment. Within this contribution 3 commonly used acid resolving agents, 2,3-dibenzoyl-L-tartaric acid, L-(+)-mandelic acid, and L-(+)-tartaric acid, are compared for the resolution of the model compound DL-serine. The behavior of each diastereomeric salt pair was analyzed experimentally and is discussed with the help of phase diagrams.

Copyright © 2011 American Chemical Society [accessed July 27th 2011]
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
External Affiliations:Otto-von-Guericke-Universität Magdeburg,
Institut für Verfahrenstechnik,
Universitätsplatz 2, 39106 Magdeburg, Germany
Identifiers:LOCALID:35/11
URL:http://dx.doi.org/10.1021/cg2001128
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