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ID: 583236.0, MPI für Evolutionsbiologie / Evolutionary ecology
Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
Authors:Eizaguirre, Christophe; Lenz, Tobias L.; Kalbe, Martin; Milinski, Manfred
Language:English
Date of Publication (YYYY-MM-DD):2012-01-10
Title of Journal:Nature Communications
Volume:3
Sequence Number of Article:621
Review Status:not specified
Audience:Not Specified
Abstract / Description:The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of this function, varying parasite-mediated selection has been proposed as a major evolutionary force for maintaining major histocompatibility complex polymorphism. A necessary prerequisite of such a balancing selection process is rapid major histocompatibility complex allele frequency shifts resulting from emerging selection by a specific parasite. Here we show in six experimental populations of sticklebacks, each exposed to one of two different parasites, that only those major histocompatibility complex alleles providing resistance to the respective specific parasite increased in frequency in the next host generation. This result demonstrates experimentally that varying parasite selection causes rapid adaptive evolutionary changes, thus facilitating the maintenance of major histocompatibility complex polymorphism.
Free Keywords:biological sciences; ecology; evolution; genetics; immunology
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsökologie
Identifiers:ISSN:2041-1723 [ID-No:1]
DOI:10.1038/ncomms1632 [ID-No:2]
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