Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Display Documents



  history
ID: 671318.0, MPI für Chemische Physik fester Stoffe / publications 2013
On the Function of Saccharides during the Nucleation of Calcium Carbonate-Protein Biocomposites
Authors:Duchstein, P.; Kniep, R.; Zahn, D.
Language:English
Date of Publication (YYYY-MM-DD):2013-11-08
Title of Journal:Crystal Growth & Design
Volume:13
Issue / Number:11
Start Page:4885
End Page:4889
Review Status:not specified
Audience:Not Specified
Abstract / Description:The molecular mechanism of calcium carbonate nucleation in the presence of various types of collageneous proteins is unravelled from computer simulation of ion-by-ion association steps. Single calcium ions are incorporated in the triplehelix by formation of salt bridges to carbonyl and hydroxyl groups of collagen, while single carbonate ions tend to bind laterally to the biomolecule. However, upon multiple ion association, the self-organization of the forming aggregate strongly depends on the triple-helical collagenous strand. In absence of glycosylated lysine residues, we observed that carbonate ions bind to calcium ions that are already incorporated into the triple helix and eventually cause the unfolding of the protein. On the other hand, otolin-1, a specific, collagen-like protein found in biogenic calcite-based composites such as otoconia, comprises a particularly high degree of glycosylated amino acids which avoid such "destructive" calcium carbonate contacts by providing alternative association sites more lateral to the backbone. This leads to the formation of a saccharide calcium carbonate agglomerate that does not compromise the protein's triple helix and constitutes the organic inorganic interface of the nucleating biocomposite.
External Publication Status:published
Document Type:Article
Communicated by:Ina Werner
Affiliations:MPI für chemische Physik fester Stoffe
Identifiers:ISI:000326775000033 [ID No:1]
ISSN:1528-7483 [ID No:2]
DOI:10.1021/cg401070h
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.