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ID: 7626.0, MPI für Evolutionsbiologie / Evolutionary ecology
Sub-lethal effects of pathogens can lead to the evolution of lower virulence in multiple infections
Authors:Schjørring, Solveig; Koella, Jacob C.
Language:English
Date of Publication (YYYY-MM-DD):2003-01-22
Title of Journal:Proceedings of the Royal Society of London Series B-Biological Sciences
Journal Abbrev.:Proc. R. Soc. Lond. Ser. B-Biol. Sci.
Volume:270
Issue / Number:1511
Start Page:189
End Page:193
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:According to current evolutionary dogma, multiple infections generally increase a parasite's virulence (i.e. reduce the host's reproductive success). The basic idea is that the competitive interactions among strains of parasites developing within a single host select individual parasites to exploit their host more rapidly than their competitors (thereby causing an increase in virulence) to ensure their transmission. Although experimental evidence is scarce, it often contradicts the theoretical expectation by suggesting that multiple infections lead to decreased virulence. Here, we present a theoretical model to explain this contradiction and show that the evolutionary outcome of multiple infections depends on the characteristics of the interaction between the host and its parasite. If we assume, as current models do, that parasites have only lethal effects on their host, multiple infections indeed increase virulence. By contrast, if parasites have sub-lethal effects on their host (such as reduced growth) and, in particular, if these effects feed back onto the parasites to reduce their rate of development, then multiplicity of infection generally leads to lower virulence
Free Keywords:epidemiology; host exploitation; life history; parasite growth; virulence; multiple infection
External Publication Status:published
Document Type:Article
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsökologie
External Affiliations:Laboratoire de Parasitologie Evolutive, CNRS-UMR 7103, Université P. & M. Curie, F-75252 Paris, France
Identifiers:ISSN:0962-8452 [ID No:1]
DOI:10.1098/rspb.2002.2233 [ID-No:2]
LOCALID:2142/S 37860 [Listen-Nummer/S-Nummer]
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