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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents

ID: 10448.0, MPI für Neurobiologie / Neuroimmunology
Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases
Authors:Kerschensteiner, Martin; Stadelmann, Christine; Dechant, Georg; Wekerle, Hartmut; Hohlfeld, Reinhard
Date of Publication (YYYY-MM-DD):2003-03
Title of Journal:Annals of Neurology
Journal Abbrev.:Ann. Neurol.
Issue / Number:3
Start Page:292
End Page:304
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Inflammatory reactions in the central nervous system usually are considered detrimental, but recent evidence suggests that they also can be beneficial and even have neuroprotective effects. Intriguingly, immune cells can produce various neurotrophic factors of various molecular families. The concept of "neuroprotective immunity" will have profound consequences for the pathogenesis and treatment of neuroinflammatory diseases such as multiple sclerosis. It also will prove important for neurodegenerative disorders, in which inflammatory reactions often occur. This review focuses on recent findings that immune cells produce brain-derived neurotrophic factor in multiple sclerosis lesions, whereas neurons and astrocytes express the appropriate tyrosine kinase receptor TrkB. Together with functional evidence for the neuroprotective effects of immune cells, these observations support the concept of "neuroprotective immunity." We next examine current and future therapeutic strategies for multiple sclerosis and experimental autoimmune encephalomyelitis in light of neuroprotective immunity and finally address the broader implications of this new concept for other neuroinflammatory and neurodegenerative diseases.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
External Affiliations:Univ Zurich, Inst Brain Res, Winterthurerstr 190, CH-8057; Zurich, Switzerland; Univ Zurich, Inst Brain Res, CH-8057 Zurich, Switzerland; Swiss Fed Inst Technol, Dept Biol, Zurich, Switzerland; Univ Goeltingen, Inst Neuropathol, Göttingen, Germany; Innsbruck Univ, Dept Neurosurg, A-6020 Innsbruck, Austria; Max Planck Inst Neurobiol, Dept Neuroimmunol, Martinsried, Germany; Univ Munich, Klinikum Grosshadern, Inst Clin Neuroimmunol, Munich, Germany
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