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          Institute: MPI für Hirnforschung     Collection: Neurochemistry (Heinrich Betz)     Display Documents

ID: 10480.0, MPI für Hirnforschung / Neurochemistry (Heinrich Betz)
Crystal structure of the GABA(A)-receptor-associated protein, GABARAP
Authors:Bavro, V. N.; Sola, M.; Bracher, A.; Kneussel, M.; Betz, H.; Weissenhorn, W.
Date of Publication (YYYY-MM-DD):2002
Title of Journal:EMBO Reports
Journal Abbrev.:EMBO Rep.
Issue / Number:2
Start Page:183
End Page:189
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The GABA(A)-receptor-associated protein (GABARAP) is a member of a growing family of intracellular membrane trafficking and/or fusion proteins and has been implicated in plasma membrane targeting and/or recycling of GABA(A) receptors. GABARAP is localized on intracellular membranes such as the trans-Golgi network, binds to the 72 subunit of GABAA receptors and interacts with microtubules and the N-ethylmaleimide- sensitive factor. We report the X-ray crystal structure of mammalian GABARAP at 2.0 Angstrom resolution. GABARAP consists of an N-terminal basic helical region, which has been implicated in tubulin binding, and a core structure with a conserved ubiquitin-like fold. Consistent with the high extent of sequence conservation among GABARAP homologues from plants to mammals, one face of the core structure is absolutely conserved while the opposite face shows considerable divergence. These features are in agreement with the conserved surface mediating protein-protein interactions shared by all members of the family, whereas the non-conserved surface region may play specific roles, such as docking to particular membrane receptors.
Comment of the Author/Creator:Date: 2002, FEB
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Hirnforschung/Neurochemistry (Abt.: Betz)
External Affiliations:European Mol Biol Lab, 6 Rue Jules Horowitz,BP181, F-38042 Grenoble 9, France
Identifiers:ISI:000174156100018 [ID No:1]
ISSN:1469-221X [ID No:2]
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