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          Institute: MPI für Hirnforschung     Collection: Neurochemistry (Heinrich Betz)     Display Documents



  history
ID: 10488.0, MPI für Hirnforschung / Neurochemistry (Heinrich Betz)
Cell type-specific expression of neuropilins in an MCA- occlusion model in mice suggests a potential role in post- ischemic brain remodeling
Authors:Beck, H.; Acker, T.; Püschel, A. W.; Fujisawa, H.; Carmeliet, P.; Plate, K. H.
Language:English
Date of Publication (YYYY-MM-DD):2002
Title of Journal:Journal of Neuropathology and Experimental Neurology
Journal Abbrev.:J. Neuropathol. Exp. Neurol.
Volume:61
Issue / Number:4
Start Page:339
End Page:350
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Neuropilin-1 and -2 (NP-1/NP-2) are transmembrane receptors that play a role in axonal guidance by binding of class III semaphorins, and in angiogenesis by binding of the vascular endothelial growth factor isoform VEGF, and placenta growth factor (PLGF). We investigated the expression pattern of NP- 1/NP-2. their co-receptors, vascular endothelial growth factor receptor-1 and -2 (VEGFR-1, VEGFR-2), and their ligands, class III semaphorins, VEGF and PLGF, following experimental cerebral ischemia in mice. By means of in situ hybridization and immunohistochemistry we observed loss of expression of class III semaphorins in neurons in the infarct/peri-infarct area. In contrast, we observed high expression of NP-1 in vessels. neurons, and astrocytes surrounding the infarct. VEGF and PLGF were upregulated in different cell types following stroke. Our results suggest a shift in the balance between semaphorins and VEGF/PLGF, which compete for NP-binding. Possibly, the loss of semaphorins facilitates binding of the competing ligands (VEGF/PLGF), thus inducing angiogenesis. In addition. the observed expression patterns further suggest a neurotrophic/neuroprotective role of VEGF/PLGF.
Free Keywords:angiogenesis; class III semaphorins; neuropilin; placenta growth factor; stroke; vascular endothelial growth factor
Comment of the Author/Creator:Date: 2002, APR
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Hirnforschung/Neurochemistry (Abt.: Betz)
External Affiliations:Univ Frankfurt, Inst Neurol, Edinger Inst, Deutschordenstr 46,; D-60528 Frankfurt, Germany; Univ Frankfurt, Inst Neurol, Edinger Inst, D-60528 Frankfurt, Germany; Max Planck Inst Brain Res, Dept Neurochem, D-6000 Frankfurt, Germany; Nagoya Univ, Grad Sch Sci, Div Biol Sci, Grp Dev Neurobiol,Chikusa Ku, Nagoya, Aichi 466, Japan; Katholieke Univ Leuven, Flanders Interuniv Biotechnol, Ctr Transgene Technol & Gene Therapy, B-3001 Louvain, Belgium
Identifiers:ISI:000174734500005 [ID No:1]
ISSN:0022-3069 [ID No:2]
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