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          Institute: MPI für Hirnforschung     Collection: Neurochemistry (Heinrich Betz)     Display Documents



  history
ID: 10505.0, MPI für Hirnforschung / Neurochemistry (Heinrich Betz)
The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFR β-containing receptors
Authors:Duong, C. V.; Geissen, M.; Rohrer, H.
Language:English
Date of Publication (YYYY-MM-DD):2002
Title of Journal:Development
Journal Abbrev.:Development
Volume:129
Issue / Number:6
Start Page:1387
End Page:1396
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRbeta as essential receptor subunit. Expression of LIFRbeta antisense RNA interfered with LIFRbeta expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons.
Free Keywords:LIF; cytokine; transmitter; plasticity; chick; noradrenergic; cholinergic; VIP
Comment of the Author/Creator:Date: 2002, MAR
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Hirnforschung/Neurochemistry (Abt.: Betz)/Rohrer (Forschungsgruppe)
Identifiers:ISI:000174824000010 [ID No:1]
ISSN:0950-1991 [ID No:2]
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