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          Institute: MPI für Hirnforschung     Collection: Neurophysiology (Wolf Singer)     Display Documents

ID: 10570.0, MPI für Hirnforschung / Neurophysiology (Wolf Singer)
Functional imaging of visuospatial processing in Alzheimer's disease
Authors:Prvulovic, D.; Hubl, D.; Sack, A. T.; Melillo, L.; Maurer, K.; Frölich, L.; Lanfermann, H.; Zanella, F. E.; Goebel, R.; Linden, D. E. J.; Dierks, T.
Date of Publication (YYYY-MM-DD):2002
Title of Journal:NeuroImage
Journal Abbrev.:Neuroimage
Issue / Number:3
Start Page:1403
End Page:1414
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Alzheimer's disease (AD) is known to cause a variety of disturbances of higher visual functions that are closely related to the neuropathological changes. Visual association areas are more affected than primary visual cortex. Additionally, there is evidence from neuropsychological and imaging studies during rest or passive visual stimulation that the occipitotemporal pathway is less affected than the parietal pathway. Our goal was to investigate functional activation patterns during active visuospatial processing in AD patients and the impact of local cerebral atrophy on the strength of functional activation. Fourteen AD patients and fourteen age- matched controls were measured with functional magnetic resonance imaging (fMRI) while they performed an angle discrimination task. Both groups revealed overlapping networks engaged in angle discrimination including the superior parietal lobule (SPL), frontal and occipitotemporal (OTC) cortical regions, primary visual cortex, basal ganglia, and thalamus. The most pronounced differences between the two groups were found in the SPL (more activity in controls) and OTC (more activity in patients). The differences in functional activation between the AD patients and controls were partly explained by the differences in individual SPL atrophy. These results indicate that parietal dysfunction in mild to moderate AD is compensated by recruitment of the ventral visual pathway. We furthermore suggest that local cerebral atrophy should be considered as a covariate in functional imaging studies of neurodegenerative disorders. (C) 2002 Elsevier Science (USA).
Comment of the Author/Creator:Date: 2002, NOV
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Hirnforschung/Neurophysiology (Abt.: Singer)/Linden (Arbeitsgruppe)
External Affiliations:Univ Frankfurt, Dept Psychiat, Lab Neurophysiol & Neuroimaging, Heinrich Hoffmann Str 10, D-60528 Frankfurt, Germany; Univ Frankfurt, Dept Neuroradiol, D-60528 Frankfurt, Germany; Univ Hosp, Psychiat Clin, Dept Psychiat Neurophysiol, Bern, Switzerland; Univ Naples Federico II, Dept Elect Engn & Telecommun, Naples, Italy; Maastricht Univ, Dept Psychol Neurocognit, Maastricht, Netherlands
Identifiers:ISI:000179012800029 [ID No:1]
ISSN:1053-8119 [ID No:2]
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