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          Institute: MPI für Neurobiologie     Collection: Molecular Neurobiology     Display Documents



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ID: 10786.0, MPI für Neurobiologie / Molecular Neurobiology
Mechanisms and functions of Eph and ephrin signalling
Authors:Kullander, K.; Klein, R.
Language:English
Date of Publication (YYYY-MM-DD):2002-07
Title of Journal:Nature Reviews Molecular Cell Biology
Journal Abbrev.:Nat. Rev. Mol. Cell Biol.
Volume:3
Issue / Number:7
Start Page:475
End Page:486
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Eph receptors constitute the largest family of tyrosine kinase receptors and, together with their plasma-membrane-bound ephrin ligands, have many important functions during development and adulthood. In contrast with most receptor tyrosine kinases, unidirectional signalling can originate from the ephrin ligands as well as from the Eph receptors. Furthermore, the concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell-cell communication.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Molecular Neurobiology (Klein)
External Affiliations:AstraZeneca Transgen & Comparat Genom, S-43183 Molndal, Sweden; AstraZeneca Transgen & Comparat Genom, S-43183 Molndal, Sweden;
Identifiers:ISI:000176563500013
ISSN:1471-0072
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