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          Institute: MPI für Hirnforschung     Collection: Neuroanatomy (Heinz Wässle)     Display Documents



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ID: 124816.0, MPI für Hirnforschung / Neuroanatomy (Heinz Wässle)
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
Authors:Altrock, W. D.; tom Dieck, S.; Sokolov, M.; Meyer, A. C.; Sigler, A.; Brakebusch, C.; Fässler, R.; Richter, K.; Boeckers, T. M.; Potschka, H.; Brandt, C.; Loscher, W.; Grimberg, D.; Dresbach, T.; Hempelmann, A.; Hassan, H.; Balschun, D.; Frey, J. U.; Brandstätter, J. H.; Garner, C. C.; Rosenmund, C.; Gundelfinger, E. D.
Language:English
Date of Publication (YYYY-MM-DD):2003
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:37
Issue / Number:5
Start Page:787
End Page:800
Review Status:not specified
Audience:Not Specified
Abstract / Description:Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.
Comment of the Author/Creator:Date: 2003, MAR 6
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Hirnforschung/Neuroanatomy (Abt.: Wässle)/Brandstätter (Arbeitsgruppe)
MPI für biophysikalische Chemie/AG Christian Rosenmund
MPI für Biochemie/Molecular Medicine (R. Fässler)
External Affiliations:Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany; Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany; Otto Von Guericke Univ, Inst Med Neurobiol, D-39120 Magdeburg, Germany; Univ Munster, Inst Anat, D-48149 Munster, Germany; Hannover Sch Vet Med, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany; Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
Identifiers:ISI:000181452800008 [ID No:1]
ISSN:0896-6273 [ID No:2]
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