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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents

ID: 124925.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A
Authors:Jensen, Vidar; Kaiser, Katharina M. M.; Borchardt, Thilo; Adelmann, Giselind; Rozov, Andrei; Burnashev, Nail; Brix, Christian; Frotscher, Michael; Andersen, Per; Hvalby, Øyvind; Sakmann, Bert; Seeburg, Peter H.; Sprengel, Rolf
Date of Publication (YYYY-MM-DD):2003-12-15
Title of Journal:Journal of Physiology
Journal Abbrev.:J. Physiol.
Issue / Number:3
Start Page:843
End Page:856
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires
L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors containing GluR-A subunits. Here, we report a GluR-A-independent form of LTP, which is comparable in size to LTP in wild-type mice at postnatal day 14 (P14) but diminishes between P14 and P42 in brain slices of GluR-A-deficient mice. The GluR-A-independent form of LTP is sensitive to D(-)-2-amino-5-phosphonopentanoic acid (D-AP5), but lacks short-term potentiation (STP) and can also be observed in the pairing induction protocol. As judged by unaltered paired-pulse facilitation, this LTP form is postsynaptically expressed despite depleted extrasynaptic AMPA receptor pools with reduced levels of GluR-B, which accumulates in somata and synapses of CA1 pyramidal neurons in GluR-A-deficient mice. Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:URI: [Abstract HTML]
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LOCALID:6002 [PUMA publication management ID]
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