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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomedizinische Optik     Display Documents



ID: 125130.0, MPI für medizinische Forschung / Abteilung Biomedizinische Optik
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction
Authors:Sidi, Samuel; Friedrich, Rainer W.; Nicolson, Teresa
Language:English
Date of Publication (YYYY-MM-DD):2003-07-04
Title of Journal:Science
Volume:301
Issue / Number:5629
Start Page:96
End Page:99
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomedizinische Optik
Relations:-URI:http://www.sciencemag.org/cgi/external_ref?access_num=2677742&link_type=MED
-URI:http://www.sciencemag.org/cgi/ijlink?linkType=ABST&journalCode=jneuro&resid=3/5/962
Identifiers:URI:http://www.sciencemag.org/cgi/content/abstract/301... [Abstract HTML]
URI:http://www.sciencemag.org/cgi/content/full/301/562... [Fulltext HTML]
URI:http://www.sciencemag.org/cgi/reprint/301/5629/96?... [Fulltext PDF]
DOI:10.1126/science.1084370
LOCALID:6034 [PUMA publication management ID]
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