Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



  history
ID: 127390.0, MPI für Neurobiologie / Neuroimmunology
Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis
Authors:Pagany, Maria; Jagodic, M.; Bourquin, Carole; Olsson, T.; Linington, Christopher
Language:English
Date of Publication (YYYY-MM-DD):2003-06
Title of Journal:Journal of Neuroimmunology
Journal Abbrev.:J. Neuroimmunol.
Volume:139
Issue / Number:1-2
Start Page:1
End Page:8
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG-EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG-EAE. (C) 2003 Elsevier Science B.V. All rights reserved.
Comment of the Author/Creator:Date: 2003, JUN
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
External Affiliations:Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany.; Karolinska Hosp, Ctr Mol Med, Neuroimmunol Unit, S-17176 Stockholm, Sweden.
Identifiers:ISI:000183899800001 [ID No:1]
ISSN:0165-5728 [ID No:2]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.