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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



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ID: 127441.0, MPI für Neurobiologie / Neuroimmunology
Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates
Authors:Pagany, Maria; Jagodic, M.; Schubart, Anna; Pham-Dinh, D.; Bachelin, C.; van Evercooren, A. B.; Lachapelle, F.; Olsson, T.; Linington, Christopher
Language:English
Date of Publication (YYYY-MM-DD):2003-10-03
Title of Journal:Neuroscience Letters
Journal Abbrev.:Neurosci. Lett.
Volume:350
Issue / Number:3
Start Page:165
End Page:168
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as demonstrated by real time PCR. A major source of this signal are Schwann cells which are also shown to express MOG protein within their cytoplasm in vitro by immunohistochemistry. Expression of MOG by Schwann cells associated with tissue innervation may account for the widespread distribution of low levels of MOG mRNA transcripts, and potentially may provide a source of antigen that can influence the composition and function of the MOG-specific immune repertoire. (C) 2003 Elsevier Ireland. All rights reserved.
Comment of the Author/Creator:Date: 2003, OCT 3
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
External Affiliations:Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany.; Karolinska Hosp, Ctr Mol Med, Neuroimmunol Unit, S-17176 Stockholm, Sweden.; Univ Paris 06, INSERM, U 546, Lab Affect Myeline & Canaux Ion Musculaires, F-75634 Paris, France.; Univ Aberdeen, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland.
Identifiers:ISI:000185589900008 [ID No:1]
ISSN:0304-3940 [ID No:2]
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