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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



  history
ID: 127474.0, MPI für Neurobiologie / Neuroimmunology
Selective unresponsiveness to conformational B cell epitopes of the myelin oligodendrocyte glycoprotein in H-2(b) mice
Authors:Bourquin, Carole; Schubart, Anna; Tobollik, S.; Mather, Ian; Ogg, S.; Liblau, Roland; Linington, Christopher
Language:English
Date of Publication (YYYY-MM-DD):2003-07-01
Title of Journal:Journal of Immunology
Journal Abbrev.:J. Immunol.
Volume:171
Issue / Number:1
Start Page:455
End Page:461
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.
Comment of the Author/Creator:Date: 2003, JUL 1
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
External Affiliations:Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany.; Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA.; Hop La Pitie Salpetriere, Inst Natl Sante & Rech Med, Unite 546, Paris, France.; Univ Aberdeen, Dept Med & Therapeut, Aberdeen, Scotland.
Identifiers:ISI:000183674400057 [ID No:1]
ISSN:0022-1767 [ID No:2]
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