MPI für molekulare Pflanzenphysiologie / Publikationen Pflanzenphysiologie |
|Parallel analysis of transcript and metabolic profiles: a new approach in systems biology|
|Authors:||Urbanczyk-Wochniak, E.; Luedemann, A.; Kopka, J.; Selbig, J.; Roessner-Tunali, U.; Willmitzer, L.; Fernie, A. R.|
|Date of Publication (YYYY-MM-DD):||2003|
|Title of Journal:||EMBO Reports|
|Issue / Number:||10|
|Review Status:||not specified|
|Abstract / Description:||The past few years in the medical and biological sciences have been characterized by the advent of systems biology. However, despite the well-known connectivity between the molecules described by transcriptomic, proteomic and metabolomic approaches, few studies have tried to correlate parameters across the various levels of systemic description. When comparing the discriminatory power of metabolic and RNA profiling to distinguish between different potato tuber systems, using the techniques described here suggests that metabolic profiling has a higher resolution than expression profiling. When applying pairwise transcript - metabolite correlation analyses, 571 of the 26,616 possible pairs showed significant correlation, most of which was novel and included several strong correlations to nutritionally important metabolites. We believe this approach to be of high potential value in the identification of candidate genes for modifying the metabolite content of biological systems. [References: 29] 29|
|Free Keywords:||Yeast. Expression. Sucrose. Identification. Arabidopsis. Proteome.
; Genomics. Starch. Arrays. Plants.
; Molecular Biology & Genetics in Current Contents(R)/Life Sciences.
; 2003 week 44
|External Publication Status:||published|
|Communicated by:||N. N.|
|Affiliations:||MPI für molekulare Pflanzenphysiologie/Molekulare Physiologie/AG Kopka|
MPI für molekulare Pflanzenphysiologie/Molekulare Physiologie/AG Willmitzer/Fernie
MPI für molekulare Pflanzenphysiologie/Zentrale Infrastrukturgruppen/AG Selbig
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