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          Institute: MPI für neurologische Forschung     Collection: Emeritus-Collection Prof. Heiss     Display Documents

ID: 13133.0, MPI für neurologische Forschung / Emeritus-Collection Prof. Heiss
Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease
Authors:Herholz, Karl; Schopphoff, H.; Schmidt, M.; Mielke, Rüdiger; Eschner, W.; Scheidhauer, K.; Schicha, H.; Heiss, Wolf-Dieter; Ebmeier, K.
Date of Publication (YYYY-MM-DD):2002-01
Title of Journal:Journal of Nuclear Medicine
Journal Abbrev.:J. Nucl. Med.
Issue / Number:1
Start Page:21
End Page:26
Copyright:Copyright 2002 by the Society of Nuclear Medicine
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Hexamethylpropyleneamine oxime (HMPAO) SPECT and F-18-FDG PET depict similar aspects of perfusion and metabolic abnormalities in Alzheimer's disease (AD), but the correspondence between them is not known in detail. We therefore used statistical parametric mapping to detect and compare abnormal brain areas objectively and quantitatively. Methods: Twenty-six patients with probable AD (mean age +/- SD, 66 +/- 9 y; mean Mini-Mental State Examination score, 22.5 +/- 4.2) and 6 nondemented healthy volunteers (mean age, 63 +/- 11 y) were studied with HMPAO SPECT and F-18-FDG PET. All images underwent the same processing steps, including 12-mm gaussian smoothing, spatial normalization, and z transformation with respect to normal average and SD, Thresholding of z maps was used to detect abnormal voxels. Results: The overall correlation between PET and SPECT across the entire brain was significant but not close (average r = 0.43). The best correspondence was found in the temporoparietal and posterior cingulate association cortices. There, the number of abnormal voxels for PET correlated strongly with the number for SPECT (r = 0.90 at a z threshold of -2.25), but tracer uptake reductions were significantly more pronounced for PET than for SPECT. Discordant findings were most frequently seen in the temporobasal and orbitofrontal areas (PET low, SPECT high) and in the cerebellum, parahippocampal cortex, and midcingulate cortex (PET high, SPECT low). The correlation between dementia severity and the number of abnormal voxels was closer for PET than for SPECT. Separation of patients from healthy volunteers by counting the number of abnormal voxels was possible over a much wider range of z thresholds with PET than with SPECT. Conclusion: Correspondence between F-18-FDG PET and HMPAO SPECT is limited to the main finding of temporoparietal and posterior cingulatelate functional impairment in mild to moderate AD. The distinction between healthy volunteers and patients is less sensitive to threshold selection with PET than with SPECT, and findings in the frontal, temporobasal, and temporomesial cortices and in the cerebellum may differ between the 2 techniques.
Free Keywords:PET; SPECT; Alzheimer's disease; Tc-99m-HMPAO; F-18-FDG
Comment of the Author/Creator:Date: 2002, JAN
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für neurologische Forschung/Allgemeine Neurologie (PET) - Abt. Prof. Heiss
External Affiliations:Max Planck Inst Neurol Res, Gleueler Str 50, D-50931 Cologne,; Germany; Max Planck Inst Neurol Res, D-50931 Cologne, Germany; Univ Cologne, Neurol Klin, D-5000 Cologne, Germany; Univ Cologne, Nukl Med Klin, Cologne, Germany; Univ Edinburgh, Dept Psychiat, Edinburgh EH8 9YL, Midlothian, Scotland
Identifiers:ISI:000173430600016 [ID No:1]
ISSN:0161-5505 [ID No:2]
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