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          Institute: MPI für Biologie     Collection: Publikationen MPI für Biologie     Display Documents

ID: 13646.0, MPI für Biologie / Publikationen MPI für Biologie
Persistence of Mhc heterozygosity in homozygous clonal killifish, Rivulus marmoratus: Implications for the origin of hermaphroditism
Authors:Sato, A.; Satta, Y.; Figueroa, F.; Mayer, W. E.; Zaleska-Rutczynska, Z.; Toyosawa, S.; Travis, J.; Klein, J.
Date of Publication (YYYY-MM-DD):2002-12
Title of Journal:Genetics
Journal Abbrev.:Genetics
Issue / Number:4
Start Page:1791
End Page:1803
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The mangrove killifish Rivulus marmoratus, a neotropical fish in the order Cyprinodontiformes, is the only known obligatorily selfing, synchronous hermaphroditic vertebrate. To shed light on its population structure and the origin of hermaphroditism, major histocompatibility complex (Mhc) class I genes of the killifish from seven different localities in Florida, Belize, and the Bahamas were cloned and sequenced. Thirteen loci and their alleles were identified and classified into eight groups. The loci apparently arose similar to20 million years ago (MYA) by gene duplications from a single common progenitor in the ancestors of R. marmoratus and its closest relatives. Distinct loci were found to be restricted to different populations and different individuals in the same population. Up to 44% of the fish were heterozygotes at Mhc loci, as compared to near homozygosity at non-Mhc loci. Large genetic distances between some of the Mhc alleles revealed the presence of ancestral allelic lineages. Computer simulation designed to explain these findings indicated that selfing is incomplete in R. marmoratus populations, that Mhc allelic lineages must have diverged before the onset of selfing, and that the hermaphroditism arose in a population containing multiple ancestral Mhc lineages. A model is proposed in which hermaphroditism arose stage-wise by mutations, each of which spread through the entire population and was fixed independently in the emerging clones.
Comment of the Author/Creator:Date: 2002, DEC
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Biologie/Abteilung Immungenetik
External Affiliations:Max Planck Inst Biol, Immungenet Abt, Correnstr 42, D-72076; Tubingen, Germany; Max Planck Inst Biol, Immungenet Abt, D-72076 Tubingen, Germany; Grad Univ Adv Studies, Dept Biosyst Sci, Hayama, Kanagawa 2400193, Japan; Florida State Univ, Dept Sci Biol, Tallahassee, FL 32306 USA
Identifiers:ISI:000180502300024 [ID No:1]
ISSN:0016-6731 [ID No:2]
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