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          Institute: MPI für Dynamik komplexer technischer Systeme     Collection: Physical and Chemical Foundations of Process Engineering     Display Documents



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ID: 13808.0, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Mathematical modelling of adsorption and transport processes in capillary electrochromatography : open-tubular geometry
Authors:Paces, M.; Kosek, J.; Marek, M.; Tallarek, U.; Seidel-Morgenstern, A.
Language:English
Date of Publication (YYYY-MM-DD):2003-02
Title of Journal:Electrophoresis
Journal Abbrev.:Electrophoresis
Volume:24
Issue / Number:3
Start Page:380
End Page:389
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:A mathematical modelling approach for open-tubular capillary electrochromatography is presented. The spatially one- dimensional model takes into account (i) a coupling of (non)linear adsorption of positively or negatively charged analyte molecules (at a negatively charged capillary inner surface) with the equilibrium electrokinetics at this solid- liquid interface, (ii) mobile phase transport by electroosmosis and pressure-driven flow, as well as (iii) transport of species by electrophoresis and molecular diffusion. Under these conditions the local zeta-potential and electroosmotic mobility become a function of the concentration of the charged analyte. The resulting inhomogeneity of electroosmotic flow through the capillary produces a compensating pore pressure as requirement for incompressible mobile phase flow (i.e., for constant volumetric flow along the capillary). The results of the simulations are discussed in view of the surface-to-volume ratio of the capillary lumen, the analyte concentration (in combination with a Langmuir isotherm for the adsorption process), and buffer effects.
Free Keywords:adsorption; capillary electrochromatography; coupled transports; electrical double layer; electroosmosis; electrophoresis; nonlinear effects
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
External Affiliations:Prague Inst Chem Technol, Dept Chem Engn, Techn 5, CZ-16628; Prague 6, Czech Republic; Otto Von Guericke Univ, Inst Proc Engn, Magdeburg, Germany
Identifiers:ISI:000180859500009
ISSN:0173-0835
LOCALID:678 35/03
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