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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents

ID: 15205.0, MPI für Neurobiologie / Neuroimmunology
Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis
Authors:Andersson, M.; Yu, M.; Soderstrom, M.; Weerth, S.; Baig, S.; Linington, C.; Solders, G.; Link, H.
Date of Publication (YYYY-MM-DD):2002-05
Title of Journal:European Journal of Neurology
Journal Abbrev.:Eur. J. Neurol.
Issue / Number:3
Start Page:243
End Page:251
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Abnormal immune responses to myelin associated glycoprotein (MAG), a component of myelin of the central and peripheral nervous system, have been suggested to play a role in the pathogenesis of multiple sclerosis (MS) and certain types of inflammatory polyneuropathy. To identify possible immunodominant MAG peptides in neuroinflammation, we examined T and B cell responses to five selected synthetic MAG peptides and myelin proteins in 21 patients with non-inflammatory polyneuropathy, 26 patients with MS, 10 optic neuritis patients and 17 healthy subjects. Enzyme-linked immunosorbent spot- forming cell assays were adopted, allowing the detection and enumeration of individual antigen responsive T and B cells in body fluids. Patients with polyneuropathy as well as those with MS had elevated levels of T and B cells recognizing MAG and its peptides. Any of the five MAG peptides under study functioned as immunodominant T and/or B cell epitope in individual subjects. None of the MAG peptides elicited a specific disease- associated T or B cell response. The enhanced T and B cell response to myelin components like MAG may play some role in initiation and/or progression of these diseases, but they could also represent secondary responses associated with myelin damage and indicate tolerization rather than autoaggressive immunity.
Free Keywords:autoimmunity; interferon-gamma; multiple sclerosis; myelin associated glycoprotein; polyneuropathy
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology
External Affiliations:Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, S-14186; Huddinge, Sweden; Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, S-14186 Huddinge, Sweden; Huddinge Univ Hosp, Karolinska Inst, Dept Ophthalmol, S-14186 Huddinge, Sweden; Max Planck Inst Psychiat, Dept Neuroimmunol, D-8033 Martinsried, Germany; Aga Khan Univ Hosp, Dept Med, Neurol Sect, Karachi, Pakistan
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