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| ID:
15205.0,
MPI für Neurobiologie / Neuroimmunology |
| Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis |
| Authors: | Andersson, M.; Yu, M.; Soderstrom, M.; Weerth, S.; Baig, S.; Linington, C.; Solders, G.; Link, H. | | Language: | English | | Date of Publication (YYYY-MM-DD): | 2002-05 | | Title of Journal: | European Journal of Neurology | | Journal Abbrev.: | Eur. J. Neurol. | | Volume: | 9 | | Issue / Number: | 3 | | Start Page: | 243 | | End Page: | 251 | | Review Status: | Peer-review | | Audience: | Not Specified | | Abstract / Description: | Abnormal immune responses to myelin associated glycoprotein (MAG), a component of myelin of the central and peripheral nervous system, have been suggested to play a role in the pathogenesis of multiple sclerosis (MS) and certain types of inflammatory polyneuropathy. To identify possible immunodominant MAG peptides in neuroinflammation, we examined T and B cell responses to five selected synthetic MAG peptides and myelin proteins in 21 patients with non-inflammatory polyneuropathy, 26 patients with MS, 10 optic neuritis patients and 17 healthy subjects. Enzyme-linked immunosorbent spot- forming cell assays were adopted, allowing the detection and enumeration of individual antigen responsive T and B cells in body fluids. Patients with polyneuropathy as well as those with MS had elevated levels of T and B cells recognizing MAG and its peptides. Any of the five MAG peptides under study functioned as immunodominant T and/or B cell epitope in individual subjects. None of the MAG peptides elicited a specific disease- associated T or B cell response. The enhanced T and B cell response to myelin components like MAG may play some role in initiation and/or progression of these diseases, but they could also represent secondary responses associated with myelin damage and indicate tolerization rather than autoaggressive immunity. | | Free Keywords: | autoimmunity; interferon-gamma; multiple sclerosis; myelin associated glycoprotein; polyneuropathy | | External Publication Status: | published | | Document Type: | Article |
| Affiliations: | MPI für Neurobiologie/Neuroimmunology
| | External Affiliations: | Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, S-14186; Huddinge, Sweden; Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, S-14186 Huddinge, Sweden; Huddinge Univ Hosp, Karolinska Inst, Dept Ophthalmol, S-14186 Huddinge, Sweden; Max Planck Inst Psychiat, Dept Neuroimmunol, D-8033 Martinsried, Germany; Aga Khan Univ Hosp, Dept Med, Neurol Sect, Karachi, Pakistan
| | Identifiers: | ISI:000175439700007
ISSN:1351-5101 | |
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