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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



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ID: 15219.0, MPI für Neurobiologie / Neuroimmunology
Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice
Authors:Campbell, P. K.; Waymire, K. G.; Heier, R. L.; Sharer, C.; Day, D. E.; Reimann, Heike; Jaje, J. M.; Friedrich, G. A.; Burmeister, M.; Bartness, T. J.; Russell, L. D.; Young, L. J.; Zimmer, M.; Jenne, Dieter E.; MacGregor, G. R.
Language:English
Date of Publication (YYYY-MM-DD):2002-09
Title of Journal:Genetics
Journal Abbrev.:Genetics
Volume:162
Issue / Number:1
Start Page:307
End Page:320
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:ROSA22 male mice arc sterile due to a recessive gene-trap mutation that affects development of the spermatid flagellum. The defect involves the flagellar axoneme, which becomes unstable around the time of its assembly. Despite a subsequent complete failure in flagellar assembly, development of the spermatid head appears normal and the spermatid head is released at the correct stage in spermatogenesis. The mutation is pleiotropic. Although ROSA22 homozygote males have normal levels of circulating testosterone and display normal mating behavior, they do not exhibit intermale aggressive behavior and have reduced body fat. The mutated gene (Gtrgeo22) maps to mouse chromosome 10 and is closely flanked by two known genes, Madcam1 and Cdc34. Ribonuclease protection analysis indicates that expression of the flanking genes is unaffected by the mutation. Gtrgeo22 is expressed at low levels in epithelial cells in several tissues, as well as in testis and brain. Analysis of the peptide coding sequence suggests that Gtrgeo22 encodes a novel transmembrane protein, which contains dileucine and tyrosine-based motifs involved in intracellular sorting of transmembrane proteins. Analysis of the Gtrgeo22 gene product should provide novel insight into the molecular basis for intermale aggression and sperm flagellar development.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
External Affiliations:Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA; Emory Univ, Sch Med, Atlanta, GA 30322 USA; Emory Univ, Grad Program Genet & Mol Biol, Atlanta, GA 30322 USA; Emory Univ, Sch Med, Ctr Mol Med, Atlanta, GA 30322 USA; Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA; Emory Univ, NSF, Ctr Behav Neurosci, Atlanta, GA 30322 USA; Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA; Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany; Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA; Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA; So Illinois Univ, Sch Med, Dept Physiol, Carbondale, IL 62901 USA; Univ Wurzburg, Inst Clin Biochem & Pathobiochem, D-97080 Wurzburg, Germany
Identifiers:ISI:000178363400025
ISSN:0016-6731
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