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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen mpi-cbg 2003     Display Documents

ID: 15408.0, MPI für molekulare Zellbiologie und Genetik / Publikationen mpi-cbg 2003
The ankyrin repeat protein diego mediates Frizzled-dependent planar polarization
Authors:Feiguin, F.; Hannus, M.; Mlodzik, M.; Eaton, S.
Date of Publication (YYYY-MM-DD):2001-07
Title of Journal:Developmental Cell
Journal Abbrev.:Dev. Cell
Issue / Number:1
Start Page:93
End Page:101
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:During planar polarization of the Drosophila wing epithelium, the homophilic adhesion molecule Flamingo localizes to proximal/distal cell boundaries in response to Frizzled signaling; perturbing Frizzled signaling alters Flamingo distribution, many cell diameters distant, by a mechanism that is not well understood. This work identifies a tissue polarity gene, diego, that comprises six ankyrin repeats and colocalizes with Flamingo at proximal/distal boundaries. Diego is specifically required for polarized accumulation of Flamingo and drives ectopic clustering of Flamingo when overexpressed. Our data suggest that Frizzled acts through Diego to promote local clustering of Flamingo, and that clustering of Diego and Flamingo in one cell nonautonomously propagates to others.
Comment of the Author/Creator:Date: 2001, JUL
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
External Affiliations:Max Planck Inst Mol Cell Biol & Genet, Pfotenhauer Str 108, D-; 01307 Dresden, Germany; Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany; European Mol Biol Lab, Cell Biol Programme, D-69117 Heidelberg, Germany; CUNY Mt Sinai Sch Med, Dept Cell Biol & Anat, New York, NY 10029 USA
Identifiers:ISI:000175301200014 [ID No:1]
ISSN:1534-5807 [ID No:2]
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