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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen mpi-cbg 2003     Display Documents

ID: 15459.0, MPI für molekulare Zellbiologie und Genetik / Publikationen mpi-cbg 2003
Tensile stress stimulates microtubule outgrowth in living cells
Authors:Kaverina, I.; Krylyshkina, O.; Beningo, K.; Anderson, K.; Wang, Y. L.; Small, J. V.
Date of Publication (YYYY-MM-DD):2002-06-01
Title of Journal:Journal of Cell Science
Journal Abbrev.:J. Cell Sci.
Issue / Number:11
Start Page:2283
End Page:2291
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Cell motility is driven by the sum of asymmetric traction forces exerted on the substrate through adhesion foci that interface with the actin cytoskeleton. Establishment of this asymmetry involves microtubules, which exert a destabilising effect on adhesion foci via targeting events. Here, we demonstrate the existence of a mechano-sensing mechanism that signals microtubule polymerisation and guidance of the microtubules towards adhesion sites under increased stress. Stress was applied either by manipulating the body of cells moving on glass with a microneedle or by stretching a flexible substrate that cells were migrating on. We propose a model for this mechano-sensing phenomenon whereby microtubule polymerisation is stimulated and guided through the interaction of a microtubule tip complex with actin filaments under tension.
Free Keywords:microtubules; actin cytoskeleton; adhesion; tension; mechanosensor
Comment of the Author/Creator:Date: 2002, JUN 1
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
External Affiliations:Austrian Acad Sci, Inst Mol Biol, Billrothstr 11, A-5020 Salzburg, Austria; Univ Massachusetts, Sch Med, Dept Physiol, Worcester, MA 01605, USA;
Identifiers:ISI:000176450900004 [ID No:1]
ISSN:0021-9533 [ID No:2]
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